Suppression of T Helper 2 Responses CellII . Qa - 1 on Activated B Cells Stimulates CD 8 Suppression of Immune Responses by CD 8 Cells

T Helper 2 Responses CellII . Qa - 1 on Activated B Cells Stimulates CD 8

Evaluation of Specific Purified TCR Effect on the Immunoregulatory Potential of TGF-beta

Transforming growth factor beta (TGF-b) is a mediator released by nearly all cell types. It has suppression activity on the immune system, but exactly how this effect is carried out is not clear. Previous experiments showed that IgG interacts with or carriers active TGF-b, that could suppresses cytotoxic T-cell responses to an immunogenic tumor in mice. Since T cell receptor (TCR) has structura...

Growth suppression effect of human mesenchymal stem cells from bone marrow, adipose tissue, and Wharton's jelly of umbilical cord on PBMCs

Objective(s):Immunosuppressive property of mesenchymal stem cells (MSCs) has great attraction in regenerative medicine especially when dealing with tissue damage involving immune reactions. The most attractive tissue sources of human MSCs used in clinical applications are bone marrow (BM), adipose tissue (AT), and Wharton's jelly (WJ) of human umbilical cord. The current study has compared immu...

بررسی تعداد سلول‌های T تنظیمی در بیماران مبتلا به بیماری کرون

Background and purpose: Crohn disease (CD) is an autoimmune disorder in which a failure of tolerance to the intestinal antigens plays a pivotal role in the pathogenesis of this disease. Treg cells control immune responses to self and foreign antigens and have an important role in maintaining self-tolerance. In this study we evaluated the frequency of Tregs in the peripheral blood of patients wi...

Transferable Anergy : Superantigen Treatment Induces CD 4 1 T Cell Tolerance That Is Reversible and Requires CD 4 2 CD 8 2 Cells and Interferon

Bacterial superantigens induce peripheral unresponsiveness in CD4 1 T cell populations that express appropriate V b chains. We have used V b 3/V a 11 T cell receptor transgenic (Tg) mice and the V b 3-specific superantigen staphylococcal enterotoxin A (SEA) to further investigate the mechanisms that contribute to such unresponsiveness. As in other models, in vivo exposure to SEA rendered the Tg...